01The Root Cause of Stomatitis
Our working hypothesis is that stomatitis is essentially an overactive immune response triggered by chronic viral infection. For reasons that aren't yet fully understood, the cat's immune system can't completely clear feline calicivirus (FCV) from the body, which keeps the immune system in a constant state of activation.
The mainstream view treats stomatitis as an autoimmune disease, but we believe that may only be the surface of the problem. The real underlying cause is likely the persistent presence of the virus, which keeps stimulating the immune system until it becomes dysregulated.
Over time this disrupts normal immune balance and keeps the immune system on high alert indefinitely. Eventually, immune cells may start mistakenly attacking the cat's own oral tissues — producing the severe inflammation we see in stomatitis.
02How Molnupiravir and CaliciPro™ Work
By using Molnupiravir and CaliciPro™, our goal is to lower the viral load in the body and reduce the continuous stimulation that virus puts on the immune system. Once that viral pressure drops, the immune system has a real chance to gradually return to balance — and only then can the chronic inflammation truly subside.
03Antivirals Alone Aren't Enough
It's important to understand that stomatitis is a very complex disease. Beyond the virus itself, it usually comes bundled with:
- Oral microbiome imbalance
- 靘菔必?抒—函?
- Tooth resorption
- Immune dysregulation from long-term inflammation
So antivirals alone usually aren't enough. In most cases the protocol also needs:
- Antibiotics
- Steroids (typically only 1–2 months)
- Oral antimicrobial products
- Lactoferrin
- Probiotics
- Dental work and extractions when needed
04Why Dental Health Matters
Dental issues are particularly important. Many stomatitis cats also have severe tooth-root disease, periodontitis, or tooth resorption hiding alongside the virus. These damaged teeth keep feeding a chronic inflammatory source — so even if the virus is controlled, the stomatitis can persist or relapse.
05Isolate in Multi-Cat Homes
Isolation in multi-cat households is also very important.
Based on more than two years of cases, ongoing contact with other cats can reduce treatment effectiveness and increase the risk of relapse. FCV is highly contagious and spreads through droplets, saliva, shared food bowls, and grooming.
06An Honest Note from Us
Finally, we want to be honest with you: this is still a relatively new direction of treatment. We've gathered a large number of successful cases and more vets are coming around to this approach, but there's still a lot about the mechanism that hasn't been fully researched.
That said, the real-world results we've seen are striking. We've watched many stomatitis cats — including some whose teeth had already all been extracted and whose disease was previously uncontrollable — improve dramatically once they started antiviral therapy.